Publications
Selected publications
Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures. Cakmak P, Lun JH, Singh A, Macas J, Schupp J, Schuck J, Mahmoud Z, Köhler M, Starzetz T, Burger MC, Steidl E, Hasse LM, Hattingen E, Plate KH, Reiss Y, Imkeller K. Immunity 2025. doi: 10.1016/j.immuni.2025.09.018
Insights, opportunities, and challenges provided by large cell atlases. Hemberg M, Marini F, Ghazanfar S, Al Ajami A, Abassi N, Anchang B, Benayoun BA, Cao Y, Chen K, Cuesta-Astroz Y, DeBruine Z, Dendrou CA, De Vlaminck I, Imkeller K, Korsunsky I, Lederer AR, Li JJ, Meysman P, Miller CL, Mullan KA, Ohler U, Panwar P, Patikas N, Schuck J, Siu JHY, Triche TJ Jr, Tsankov A, van der Laan SW, Yajima M, Yang J, Zanini F, Jelic I. Genome Biology 2025. doi: 10.1186/s13059-025-03771-8
A comprehensive workflow for allele-specific immune gene quantification and expression analysis in single-cell RNA-seq data. Al Ajami A, Schuck J, Marini F, Imkeller K. NARGAB 2025. doi: 10.1093/nargab/lqaf149
Modulation of the ATP-adenosine signaling axis combined with radiotherapy facilitates anti-cancer immunity in brain metastasis. Salamero-Boix A, Schulz M, Anthes J, Mayer J, Möckl A, Tsoukala I, Menger D, Mosa MH, Hetzer J, Macas J, Hehlgans S, Schuck J, Roller B, Reiss Y, Hochart G, Bonnel D, Medyouf H, Rodriguez MB, Broggini T, Czabanka M, Plate KH, Heikenwälder M, Rödel F, Harter PN, Imkeller K, Sevenich L. bioRxiv; 2024. doi: 10.1101/2024.09.30.615883.
CRISPR/Cas9 editing of NKG2A improves the efficacy of primary CD33-directed chimeric antigen receptor natural killer cells. Bexte T, Albinger N, Al Ajami A, Wendel P, Buchinger L, Gessner A, Alzubi J, Särchen V, Vogler M, Rasheed HM, Jung BA, Wolf S, Bhayadia R, Oellerich T, Klusmann JH, Penack O, Möker N, Cathomen T, Rieger MA, Imkeller K, Ullrich E. Nat Commun. 2024 Sep;15(1):8439. doi: 10.1038/s41467-024-52388-1.
Cytokine-responsive T- and NK-cells portray SARS-CoV-2 vaccine-responders and infection in multiple myeloma patients. Enssle JC, Campe J, Moter A, Voit I, Gessner A, Yu W, Wolf S, Steffen B, Serve H, Bremm M, Huenecke S, Lohoff M, Vehreschild M, Rabenau HF, Widera M, Ciesek S, Oellerich T, Imkeller K, Rieger MA, von Metzler I, Ullrich E. Leukemia. 2024 Jan;38(1):168-180. doi: 10.1038/s41375-023-02070-0.
BSc and MSc theses
| Title | Author | Degree |
|---|---|---|
| Inferring cell-cell interactions in the brain metastasis microenvironment | Jens Mayer | MSc Bioinformatics (Goethe University) |
| Development of a multi-layer R object to study immune gene expression in spatial (and single-cell) transcriptomics at allele, gene and functional level | Jonas Schuck | MSc Bioinformatics (Goethe University) |
| Linking Adaptive Immune Receptor Repertoires to Spatial Organization of Tumor Infiltrating Lymphocytes | Lucie Marie Hasse | BSc Bioinformatics (Goethe University) |